Public authorities have advised against making the journey to Lewes for Bonfire Night because of the expected crowds and the associated safety risks.
Emergency services, local councils and transport companies have spent several months preparing for the annual event on November 5.
Lewes regularly receives large numbers of visitors, while previous celebrations have resulted in injuries, particularly on the town’s narrow streets.
East Sussex Fire and Rescue Service group manager Paul Coppard asked residents to support organised fireworks displays in their own areas rather than visit Lewes on November 5.
He said the service had been working with event organisers and partner agencies on plans intended to protect communities across East Sussex.
He also encouraged people to observe bonfire guidance and the fireworks code, while following official safety advice to prevent unnecessary risks to themselves or others.
Rail services will not call at Lewes, Falmer, Cooksbridge, Glynde or Southease from 5pm on November 5 until services resume on November 6.
The final trains serving those stations from London Victoria are scheduled to leave at 3.24pm and 3.54pm.
A series of road restrictions will take effect from 4.45pm on Thursday, November 5.
Lewes residents have been advised to bring vehicles home before 4pm to avoid delays and disruption.
The affected roads include the A27 at A277 Brighton Road near Ashcombe Roundabout, A275 Offham Road at B2116 Plumpton Road, C7 Kingston Road at C324 Wellgreen Lane, A26 at A2029 Malling Street, A26 Church Lane at Mayhew Way, and The Drove at Hamsey Lane leading to the A275.
Parking restrictions will begin at noon on November 5.
According to Lewes District Council, the measures are required because there is a very high likelihood of an incident.
The authority considers its response appropriate and proportionate given the event’s continued popularity and the severe overcrowding normally experienced in Lewes.
It said restrictions would help protect people by reducing attendance at a celebration that can become dangerously congested.
Safety reports have concluded that leaving the arrangements unchanged could result in serious injury or the death of one or more people.
Chief Superintendent Graham Barnett of Sussex Police said officers would work alongside organisers, stewarding teams and other partners to make the occasion safe and enjoyable.
Police patrols will be visible throughout the event, and criminal or anti-social conduct will face enforcement.
Authorities will act against anyone who endangers others or disregards restrictions, including visitors bringing their own fireworks.
A substantial police presence and close coordination between agencies, bonfire societies and organisers are planned.
Steward and police personnel will remain alert, with unusual or suspicious activity to be reported to a steward or officer; emergencies should be directed to 999.
Officials have also warned that the event is unsuitable for young children and dogs because of the noise, smoke, dense crowds and the town’s layout.